Please look after yourself and your fellow clubbers. Watch for dehydration and heatstroke. The main symptoms are excessive sweating, staggering, thirst and exhaustion. Over heating is unlikely to occur if enough water is drunk.
Dr. John Henry from the National Poisons Unit at Guy's Hospital, London explains the mechanism of heat stroke. Dissolute Intravascular Coagulation (DIC) - blood clotting in the arteries - occurs at 42 - 43 degrees centigrade (c.108 degrees Fahrenheit) and tiny blood clots stick to the artery wall. This is harmless in itself, as the blood clots are too small to cause a blockage, but the process can use up all the clotting agent, with the result that the blood will pour out of any of the tiny haemorrages which occur throughout the cardovascular system as part of the normal process of breakdown and repair. Such internal bleeding can be fatal. Internal bleeding in the brain, combined with high, pulsating blood pressures can cause shakes.
To combat this, SIP SOME WATER
Dr Henry believes MDMA stimulates opioids, a neuro-transmitter that acts as an internal anaesthetic. Neuro-transmitters such as 5HT and opioids can be stimulated by chemicals such as MDMA. Opioids go into action when the body is injured, so if your body is exhausted or overheating you can't feel that it is.
Kidney failure (or "acute renal failure") is the result of muscular breakdown overloading the kidneys with myglobin. Muscular breakdown can be caused by intense bouts of physical exercise.
In other words, REST FREQUENTLY. COOL DOWN.
There may also be a link between liver damage and ecstasy use. Liver damage cases in the UK "might be the result of parallel use of alcohol and other drugs".
So, DON'T DRINK ALCOHOL or MIX OTHER DRUGS WITH YOUR E
Finally, MDMA can undergo "redox cycling" - a process that liberates copious quantities of oxygen free radicals. Excessive amounts overwhelm the system and damage ensues. Phenethylamines are stored in highest concetrations in the brain and nervous system. Not surprisingly these tissues are at the greatest risk for being harmed by free radicals (and associated oxidants) formed during the redox cycling of phenethylamines.
Excessive quantities may cause oxidative damage. It would therefore be prudent for those taking large quantities of MDMA to take antioxidant supplements as well. These incude Vitamin C (2-4 grams) which is water soluble and Vitamin E (1000 iu) which is fat soluble.Also recommended; B-Carotene (5mg); Bioflavonoids (2gm); L-Carnitine (1gm); N-Acetylcysteine (2gm); Selenium (250mcg)
TAKE EXTRA VITAMINS